CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897
TGFR1_HUMAN
Homo sapiens
TGF-beta receptor type-1

PDB Structure

PDB 6B8Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF beta RI).
Harikrishnan, L.S., Warrier, J., Tebben, A.J., Tonukunuru, G., Madduri, S.R., Baligar, V., Mannoori, R., Seshadri, B., Rahaman, H., Arunachalam, P.N., Dikundwar, A.G., Fink, B.E., Fargnoli, J., Fereshteh, M., Fan, Y., Lippy, J., Ho, C.P., Wautlet, B., Sheriff, S., Ruzanov, M., Borzilleri, R.M.
Bioorg. Med. Chem.