CATH Classification

Domain Context

CATH Clusters

Superfamily Receptor L-domain
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P00533
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533
EGFR_HUMAN
Homo sapiens
Epidermal growth factor receptor

PDB Structure

PDB 6B3S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance.
Bagchi, A., Haidar, J.N., Eastman, S.W., Vieth, M., Topper, M., Iacolina, M.D., Walker, J.M., Forest, A., Shen, Y., Novosiadly, R.D., Ferguson, K.M.
Mol. Cancer Ther.