CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P9WI83
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P9WI83
PKNA_MYCTU
Mycobacterium tuberculosis H37Rv
Serine/threonine-protein kinase PknA

PDB Structure

PDB 6B2Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
Wang, T., Bemis, G., Hanzelka, B., Zuccola, H., Wynn, M., Moody, C.S., Green, J., Locher, C., Liu, A., Gao, H., Xu, Y., Wang, S., Wang, J., Bennani, Y.L., Thomson, J.A., Muh, U.
ACS Med Chem Lett