CATH Domain 6alnA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.130	Double-stranded beta-helix
	3.60.130.10	Clavaminate synthase-like

Domain Context

CATH Clusters

Superfamily	Clavaminate synthase-like
Functional Family	Alpha-ketoglutarate-dependent L-arginine hydroxylase

Enzyme Information

1.14.11.41

L-arginine hydroxylase.

based on mapping to UniProt Q6WZB0

L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2).

-!- The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. -!- It differs from EC 1.14.20.7, because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.

UniProtKB Entries (1)

Q6WZB0

ARGHX_STRVI

Streptomyces vinaceus

Alpha-ketoglutarate-dependent L-arginine hydroxylase

PDB Structure

PDB	6ALN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase. Mitchell, A.J., Dunham, N.P., Martinie, R.J., Bergman, J.A., Pollock, C.J., Hu, K., Allen, B.D., Chang, W.C., Silakov, A., Bollinger, J.M., Krebs, C., Boal, A.K. J. Am. Chem. Soc.