CATH Classification

Domain Context

CATH Clusters

Superfamily Clavaminate synthase-like
Functional Family Alpha-ketoglutarate-dependent L-arginine hydroxylase

Enzyme Information

1.14.11.41
L-arginine hydroxylase.
based on mapping to UniProt Q6WZB0
L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2).
-!- The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. -!- It differs from EC 1.14.20.7, because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.

UniProtKB Entries (1)

Q6WZB0
ARGHX_STRVI
Streptomyces vinaceus
Alpha-ketoglutarate-dependent L-arginine hydroxylase

PDB Structure

PDB 6ALN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase.
Mitchell, A.J., Dunham, N.P., Martinie, R.J., Bergman, J.A., Pollock, C.J., Hu, K., Allen, B.D., Chang, W.C., Silakov, A., Bollinger, J.M., Krebs, C., Boal, A.K.
J. Am. Chem. Soc.