CATH Domain 5z9yA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

2.8.1.10

Thiazole synthase.

based on mapping to UniProt P9WG73

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur- carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)- ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O.

-!- H(2)S can provide the sulfur in vitro. -!- Part of the pathway for thiamine biosynthesis.

UniProtKB Entries (1)

P9WG73

THIG_MYCTU

Mycobacterium tuberculosis H37Rv

Thiazole synthase

PDB Structure

PDB	5Z9Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Snapshots of catalysis: Structure of covalently bound substrate trapped in Mycobacterium tuberculosis thiazole synthase (ThiG). Zhang, J., Zhang, B., Zhao, Y., Yang, X., Huang, M., Cui, P., Zhang, W., Li, J., Zhang, Y. Biochem. Biophys. Res. Commun.