CATH Domain 5yigA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	DNA gyrase subunit B

Enzyme Information

UniProtKB Entries (1)

G6JAH7_STREE

Streptococcus pneumoniae GA47502

DNA topoisomerase 4 subunit B

PDB Structure

PDB	5YIG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria. Ho, S.Y., Wang, W., Ng, F.M., Wong, Y.X., Poh, Z.Y., Tan, S.W.E., Ang, S.H., Liew, S.S., Joyner Wong, Y.S., Tan, Y., Poulsen, A., Pendharkar, V., Sangthongpitag, K., Manchester, J., Basarab, G., Hill, J., Keller, T.H., Cherian, J. Eur J Med Chem