CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.240 | ProC C-terminal domain-like fold |
|
6.10.240.10 |
Domain Context
CATH Clusters
| Superfamily | 6.10.240.10 |
| Functional Family |
Enzyme Information
| 1.1.1.86 |
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt Q4J8K9
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.
|
UniProtKB Entries (1)
| Q4J8K9 |
ILVC_SULAC
Sulfolobus acidocaldarius DSM 639
Ketol-acid reductoisomerase (NADP(+))
|
PDB Structure
| PDB | 5YEQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius
Sci Rep
|