CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Aspartokinase

Enzyme Information

2.7.2.4
Aspartate kinase.
based on mapping to UniProt O69077
ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

O69077
AK_PSEAE
Pseudomonas aeruginosa PAO1
Aspartokinase

PDB Structure

PDB 5YEI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanistic insights into the allosteric regulation of Pseudomonas aeruginosa aspartate kinase.
Li, C., Yang, M., Liu, L., Li, T., Peng, C., He, L., Song, Y., Zhu, Y., Shen, Y., Yang, J., Zhao, N., Zhao, C., Zhou, Q., Li, H., Kang, M., Tong, A., Tang, H., Bao, R.
Biochem.J.