CATH Domain 5yeiA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1160	Carbamate kinase
	3.40.1160.10	Acetylglutamate kinase-like

Domain Context

CATH Clusters

Superfamily	Acetylglutamate kinase-like
Functional Family	Aspartokinase

Enzyme Information

2.7.2.4

Aspartate kinase.

based on mapping to UniProt O69077

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

-!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 1.1.1.3. -!- This is also the case for two of the four isoenzymes in Arabidopsis thaliana. -!- The equilibrium constant strongly favors the reaction from right to left, i.e. the non-physiological direction of reaction.

UniProtKB Entries (1)

O69077

AK_PSEAE

Pseudomonas aeruginosa PAO1

Aspartokinase

PDB Structure

PDB	5YEI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanistic insights into the allosteric regulation of Pseudomonas aeruginosa aspartate kinase. Li, C., Yang, M., Liu, L., Li, T., Peng, C., He, L., Song, Y., Zhu, Y., Shen, Y., Yang, J., Zhao, N., Zhao, C., Zhou, Q., Li, H., Kang, M., Tong, A., Tang, H., Bao, R. Biochem.J.