CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Enoyl-[acyl-carrier-protein] reductase [NADH] |
Enzyme Information
| 1.3.1.9 |
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt Q81GI3
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.
|
UniProtKB Entries (1)
| Q81GI3 |
FABI_BACCR
Bacillus cereus ATCC 14579
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
|
PDB Structure
| PDB | 5YCX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into the dimer-tetramer transition of FabI from Bacillus anthracis
Biochem. Biophys. Res. Commun.
|