CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9
Enoyl-[acyl-carrier-protein] reductase (NADH).
based on mapping to UniProt Q81GI3
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

Q81GI3
FABI_BACCR
Bacillus cereus ATCC 14579
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

PDB Structure

PDB 5YCS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the dimer-tetramer transition of FabI from Bacillus anthracis
Kim, H.T., Kim, S., Na, B.K., Chung, J., Hwang, E., Hwang, K.Y.
Biochem. Biophys. Res. Commun.