CATH Domain 5wteB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.20

Domain Context

CATH Clusters

Superfamily	2.60.120.20
Functional Family	Genome polyprotein

Enzyme Information

3.4.22.28	Picornain 3C. based on mapping to UniProt P08617 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt P08617 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P08617 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

POLG_HAVHM

Human hepatitis A virus Hu/Australia/HM175/1976

Genome polyprotein

PDB Structure

PDB	5WTE
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Kotecha, A., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z. Proc. Natl. Acad. Sci. U.S.A.