CATH Classification

Domain Context

CATH Clusters

Superfamily Son of sevenless (SoS) protein Chain: S domain 1
Functional Family son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

P01112
RASH_HUMAN
Homo sapiens
GTPase HRas

PDB Structure

PDB 5WFO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns, M.C., Howes, J.E., Sun, Q., Little, A.J., Camper, D.V., Abbott, J.R., Phan, J., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W.
Anal. Biochem.