CATH Classification

Domain Context

CATH Clusters

Superfamily Anticodon-binding domain
Functional Family histidine--tRNA ligase, cytoplasmic isoform X1

Enzyme Information

UniProtKB Entries (0)

PDB Structure

PDB 5W6M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Blocquel, D., Sun, L., Matuszek, Z., Li, S., Weber, T., Kuhle, B., Kooi, G., Wei, N., Baets, J., Pan, T., Schimmel, P., Yang, X.L.
Proc.Natl.Acad.Sci.USA