CATH Domain 5vrlA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

1.3.1.9

Enoyl-[acyl-carrier-protein] reductase (NADH).

based on mapping to UniProt P9WGR0

An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.

-!- The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety. -!- The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. -!- The FAS-I enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.

UniProtKB Entries (1)

P9WGR0

INHA_MYCTO

Mycobacterium tuberculosis CDC1551

Enoyl-[acyl-carrier-protein] reductase [NADH]

PDB Structure

PDB	5VRL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA. Xia, Y., Zhou, Y., Carter, D.S., McNeil, M.B., Choi, W., Halladay, J., Berry, P.W., Mao, W., Hernandez, V., O'Malley, T., Korkegian, A., Sunde, B., Flint, L., Woolhiser, L.K., Scherman, M.S., Gruppo, V., Hastings, C., Robertson, G.T., Ioerger, T.R., Sacchettini, J., Tonge, P.J., Lenaerts, A.J., Parish, T., Alley, M. Life Sci Alliance