1 keywords

CATH Domain 5vdoB02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.460 Beta Polymerase; domain 2
Homologous Superfamily 3.30.460.90  

Domain Context

CATH Clusters

Superfamily 3.30.460.90
Functional Family Cyclic GMP-AMP synthase

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8N884
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

Q8N884
CGAS_HUMAN
Homo sapiens
Cyclic GMP-AMP synthase

PDB Structure

PDB 5VDO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Hall, J., Ralph, E.C., Shanker, S., Wang, H., Byrnes, L.J., Horst, R., Wong, J., Brault, A., Dumlao, D., Smith, J.F., Dakin, L.A., Schmitt, D.C., Trujillo, J., Vincent, F., Griffor, M., Aulabaugh, A.E.
Protein Sci.