CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family

Enzyme Information

3.4.23.5
Cathepsin D.
based on mapping to UniProt P24268
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
-!- Occurs intracellularly, in lysosomes. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.23.

UniProtKB Entries (1)

P24268
CATD_RAT
Rattus norvegicus
Cathepsin D

PDB Structure

PDB 5UX4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Low, J.D., Bartberger, M.D., Chen, K., Cheng, Y., Fielden, M.R., Gore, V., Hickman, D., Liu, Q., Allen Sickmier, E., Vargas, H.M., Werner, J., White, R.D., Whittington, D.A., Wood, S., Minatti, A.E.
Medchemcomm