CATH Domain 5uwgA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2000	Frizzled cysteine-rich domain
	1.10.2000.10	Frizzled cysteine-rich domain

Domain Context

CATH Clusters

Superfamily	Frizzled cysteine-rich domain
Functional Family	Frizzled receptor 4

Enzyme Information

UniProtKB Entries (1)

FZD4_HUMAN

Homo sapiens

Frizzled-4

PDB Structure

PDB	5UWG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. DeBruine, Z.J., Ke, J., Harikumar, K.G., Gu, X., Borowsky, P., Williams, B.O., Xu, W., Miller, L.J., Xu, H.E., Melcher, K. Genes Dev.