CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O60674
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674
JAK2_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK2

PDB Structure

PDB 5USY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.
Puleo, D.E., Kucera, K., Hammaren, H.M., Ungureanu, D., Newton, A.S., Silvennoinen, O., Jorgensen, W.L., Schlessinger, J.
ACS Med Chem Lett