CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt P05979
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

P05979
PGH1_SHEEP
Ovis aries
Prostaglandin G/H synthase 1

PDB Structure

PDB 5U6X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).
Cingolani, G., Panella, A., Perrone, M.G., Vitale, P., Di Mauro, G., Fortuna, C.G., Armen, R.S., Ferorelli, S., Smith, W.L., Scilimati, A.
Eur J Med Chem