CATH Domain 5u0kI00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.20	Ankyrin repeat-containing domain

Domain Context

CATH Clusters

Superfamily	Ankyrin repeat-containing domain
Functional Family	Glutaminase liver isoform, mitochondrial

Enzyme Information

3.5.1.2

Glutaminase.

based on mapping to UniProt Q9UI32

L-glutamine + H(2)O = L-glutamate + NH(3).

UniProtKB Entries (1)

GLSL_HUMAN

Homo sapiens

Glutaminase liver isoform, mitochondrial

PDB Structure

PDB	5U0K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats. Pasquali, C.C., Islam, Z., Adamoski, D., Ferreira, I.M., Righeto, R.D., Bettini, J., Portugal, R.V., Yue, W.W., Gonzalez, A., Dias, S.M.G., Ambrosio, A.L.B. J. Biol. Chem.