CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.3
Cysteine transaminase.
based on mapping to UniProt P00503
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00503
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P00503
AATC_PIG
Sus scrofa
Aspartate aminotransferase, cytoplasmic

PDB Structure

PDB 5TOQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Direct evidence that an extended hydrogen-bonding network influences activation of pyridoxal 5'-phosphate in aspartate aminotransferase.
Dajnowicz, S., Parks, J.M., Hu, X., Gesler, K., Kovalevsky, A.Y., Mueser, T.C.
J. Biol. Chem.