CATH Domain 5tjxA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.34

Plasma kallikrein.

based on mapping to UniProt P03952

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

-!- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. -!- Activates coagulation factors XII, VII and plasminogen. -!- Selective for Arg > Lys in P1, in small molecule substrates. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.21 and EC 3.4.21.8.

UniProtKB Entries (1)

P03952

KLKB1_HUMAN

Homo sapiens

Plasma kallikrein

PDB Structure

PDB	5TJX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors. Li, Z., Partridge, J., Silva-Garcia, A., Rademacher, P., Betz, A., Xu, Q., Sham, H., Hu, Y., Shan, Y., Liu, B., Zhang, Y., Shi, H., Xu, Q., Ma, X., Zhang, L. ACS Med Chem Lett