CATH Domain 5tj3A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1360	Gyrase A; domain 2
	3.30.1360.150

Domain Context

CATH Clusters

Superfamily	3.30.1360.150
Functional Family	Alkaline phosphatase PafA

Enzyme Information

3.1.3.1

Alkaline phosphatase.

based on mapping to UniProt Q9KJX5

A phosphate monoester + H(2)O = an alcohol + phosphate.

-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

Q9KJX5

ALPH_ELIME

Elizabethkingia meningoseptica

Alkaline phosphatase PafA

PDB Structure

PDB	5TJ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily. Sunden, F., AlSadhan, I., Lyubimov, A.Y., Ressl, S., Wiersma-Koch, H., Borland, J., Brown, C.L., Johnson, T.A., Singh, Z., Herschlag, D. J.Am.Chem.Soc.