CATH Domain 5tj3A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.720	Alkaline Phosphatase, subunit A
	3.40.720.10	Alkaline Phosphatase, subunit A

Domain Context

CATH Clusters

Superfamily	Alkaline Phosphatase, subunit A
Functional Family	Alkaline phosphatase PafA

Enzyme Information

3.1.3.1

Alkaline phosphatase.

based on mapping to UniProt Q9KJX5

A phosphate monoester + H(2)O = an alcohol + phosphate.

-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

Q9KJX5

ALPH_ELIME

Elizabethkingia meningoseptica

Alkaline phosphatase PafA

PDB Structure

PDB	5TJ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily. Sunden, F., AlSadhan, I., Lyubimov, A.Y., Ressl, S., Wiersma-Koch, H., Borland, J., Brown, C.L., Johnson, T.A., Singh, Z., Herschlag, D. J.Am.Chem.Soc.