CATH Classification

Domain Context

CATH Clusters

Superfamily Tyrosyl-Transfer RNA Synthetase
Functional Family Tyrosine--tRNA ligase

Enzyme Information

6.1.1.1
Tyrosine--tRNA ligase.
based on mapping to UniProt P54577
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

UniProtKB Entries (1)

P54577
SYYC_HUMAN
Homo sapiens
Tyrosine--tRNA ligase, cytoplasmic

PDB Structure

PDB 5THH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Blocquel, D., Li, S., Wei, N., Daub, H., Sajish, M., Erfurth, M.L., Kooi, G., Zhou, J., Bai, G., Schimmel, P., Jordanova, A., Yang, X.L.
Nucleic Acids Res.