1 keywords

CATH Domain 5tf9A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.510 Transferase(Phosphotransferase); domain 1
Homologous Superfamily 1.10.510.10 Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase WNK1 isoform 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9H4A3
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9H4A3
WNK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase WNK1

PDB Structure

PDB 5TF9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
Yamada, K., Zhang, J.H., Xie, X., Reinhardt, J., Xie, A.Q., LaSala, D., Kohls, D., Yowe, D., Burdick, D., Yoshisue, H., Wakai, H., Schmidt, I., Gunawan, J., Yasoshima, K., Yue, Q.K., Kato, M., Mogi, M., Idamakanti, N., Kreder, N., Drueckes, P., Pandey, P., Kawanami, T., Huang, W., Yagi, Y.I., Deng, Z., Park, H.M.
ACS Chem. Biol.