1 keywords

CATH Domain 5tbmB01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.450 Beta-Lactamase
Homologous Superfamily 3.30.450.20 PAS domain

Domain Context

CATH Clusters

Superfamily PAS domain
Functional Family Aryl hydrocarbon receptor nuclear translocator 1

Enzyme Information

UniProtKB Entries (1)

Q99814
EPAS1_HUMAN
Homo sapiens
Endothelial PAS domain-containing protein 1

PDB Structure

PDB 5TBM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Wallace, E.M., Rizzi, J.P., Han, G., Wehn, P.M., Cao, Z., Du, X., Cheng, T., Czerwinski, R.M., Dixon, D.D., Goggin, B.S., Grina, J.A., Halfmann, M.M., Maddie, M.A., Olive, S.R., Schlachter, S.T., Tan, H., Wang, B., Wang, K., Xie, S., Xu, R., Yang, H., Josey, J.A.
Cancer Res.