CATH Domain 5t31B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P49841 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26	[Tau protein] kinase. based on mapping to UniProt P49841 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

GSK3B_HUMAN

Homo sapiens

Glycogen synthase kinase-3 beta

PDB Structure

PDB	5T31
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Wagner, F.F., Benajiba, L., Campbell, A.J., Weiwer, M., Sacher, J.R., Gale, J.P., Ross, L., Puissant, A., Alexe, G., Conway, A., Back, M., Pikman, Y., Galinsky, I., DeAngelo, D.J., Stone, R.M., Kaya, T., Shi, X., Robers, M.B., Machleidt, T., Wilkinson, J., Hermine, O., Kung, A., Stein, A.J., Lakshminarasimhan, D., Hemann, M.T., Scolnick, E., Zhang, Y.L., Pan, J.Q., Stegmaier, K., Holson, E.B. Sci Transl Med