CATH Domain 5t0mA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q96KQ7 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q96KQ7

UniProtKB Entries (1)

H31_HUMAN

Homo sapiens

Histone H3.1

PDB Structure

PDB	5T0M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Shan, C.M., Wang, J., Xu, K., Chen, H., Yue, J.X., Andrews, S., Moresco, J.J., Yates, J.R., Nagy, P.L., Tong, L., Jia, S. Elife