CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 5SZ9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.
Imaeda, Y., Tawada, M., Suzuki, S., Tomimoto, M., Kondo, M., Tarui, N., Sanada, T., Kanagawa, R., Snell, G., Behnke, C.A., Kubo, K., Kuroita, T.
Bioorg.Med.Chem.
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