CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 5SZ5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.
Bhatt, A., Mahon, B.P., Cruzeiro, V.W., Cornelio, B., Laronze-Cochard, M., Ceruso, M., Sapi, J., Rance, G.A., Khlobystov, A.N., Fontana, A., Roitberg, A., Supuran, C.T., McKenna, R.
Chembiochem
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