CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.420 | Peroxidase; domain 2 | |
1.10.420.10 | Peroxidase, domain 2 |
Domain Context
CATH Clusters
Superfamily | Peroxidase, domain 2 |
Functional Family | Catalase-peroxidase |
Enzyme Information
1.11.1.21 |
Catalase peroxidase.
based on mapping to UniProt Q3JNW6
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.
|
UniProtKB Entries (1)
Q3JNW6 |
KATG_BURP1
Burkholderia pseudomallei 1710b
Catalase-peroxidase
|
PDB Structure
PDB | 5SYV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.
Biochemistry
|