CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt Q3JNW6
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

Q3JNW6
KATG_BURP1
Burkholderia pseudomallei 1710b
Catalase-peroxidase

PDB Structure

PDB 5SYI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding of the antitubercular pro-drug isoniazid in the heme access channel of catalase-peroxidase (KatG). A combined structural and metadynamics investigation.
Vidossich, P., Loewen, P.C., Carpena, X., Fiorin, G., Fita, I., Rovira, C.
J Phys Chem B