CATH Domain 5qcnA02

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Coagulation factor XI

3.4.21.27

Coagulation factor XIa.

based on mapping to UniProt P03951

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

FA11_HUMAN

Homo sapiens

Coagulation factor XI

PDB	5QCN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). Pinto, D.J.P., Orwat, M.J., Smith, L.M., Quan, M.L., Lam, P.Y.S., Rossi, K.A., Apedo, A., Bozarth, J.M., Wu, Y., Zheng, J.J., Xin, B., Toussaint, N., Stetsko, P., Gudmundsson, O., Maxwell, B., Crain, E.J., Wong, P.C., Lou, Z., Harper, T.W., Chacko, S.A., Myers, J.E., Sheriff, S., Zhang, H., Hou, X., Mathur, A., Seiffert, D.A., Wexler, R.R., Luettgen, J.M., Ewing, W.R. J. Med. Chem.