CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.390 | Neutral Protease; domain 2 |
|
1.10.390.10 | Neutral Protease Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Neutral Protease Domain 2 |
| Functional Family | Thermolysin |
Enzyme Information
| 3.4.24.27 |
Thermolysin.
based on mapping to UniProt P43133
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (2)
| P43133 |
THER_GEOSE
Geobacillus stearothermophilus
Thermolysin
|
| P05067 |
A4_HUMAN
Homo sapiens
Amyloid-beta precursor protein
|
PDB Structure
| PDB | 5ONQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett.
|