CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 5OBJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
Cole, D.J., Janecek, M., Stokes, J.E., Rossmann, M., Faver, J.C., McKenzie, G.J., Venkitaraman, A.R., Hyvonen, M., Spring, D.R., Huggins, D.J., Jorgensen, W.L.
Chem. Commun. (Camb.)