CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.1580 | paralog of FGE (formylglycine-generating enzyme) | |
3.90.1580.10 | paralog of FGE (formylglycine-generating enzyme) |
Domain Context
CATH Clusters
Superfamily | paralog of FGE (formylglycine-generating enzyme) |
Functional Family |
Enzyme Information
1.8.3.7 |
Formylglycine-generating enzyme.
based on mapping to UniProt D1A7C3
A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L- alanine + hydrogen sulfide + a disulfide + H(2)O.
-!- The enzyme, which is found in both prokaryotes and eukaryotes, catalyzes a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity. -!- The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro. -!- Glutathione alo acts in vitro, but it is not known whether it is used in vivo.
|
UniProtKB Entries (1)
D1A7C3 |
FGE_THECD
Thermomonospora curvata DSM 43183
Formylglycine-generating enzyme
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PDB Structure
PDB | 5NYY |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme.
Angew. Chem. Int. Ed. Engl.
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