CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1580 | paralog of FGE (formylglycine-generating enzyme) |
|
3.90.1580.10 | paralog of FGE (formylglycine-generating enzyme) |
Domain Context
CATH Clusters
| Superfamily | paralog of FGE (formylglycine-generating enzyme) |
| Functional Family |
Enzyme Information
| 1.8.3.7 |
Formylglycine-generating enzyme.
based on mapping to UniProt D1A7C3
A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L- alanine + hydrogen sulfide + a disulfide + H(2)O.
-!- The enzyme, which is found in both prokaryotes and eukaryotes, catalyzes a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity. -!- The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro. -!- Glutathione alo acts in vitro, but it is not known whether it is used in vivo.
|
UniProtKB Entries (1)
| D1A7C3 |
FGE_THECD
Thermomonospora curvata DSM 43183
Formylglycine-generating enzyme
|
PDB Structure
| PDB | 5NXL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme.
Angew. Chem. Int. Ed. Engl.
|