CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P22455
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P22455
FGFR4_HUMAN
Homo sapiens
Fibroblast growth factor receptor 4

PDB Structure

PDB 5NWZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.
Fairhurst, R.A., Knoepfel, T., Leblanc, C., Buschmann, N., Gaul, C., Blank, J., Galuba, I., Trappe, J., Zou, C., Voshol, J., Genick, C., Brunet-Lefeuvre, P., Bitsch, F., Graus-Porta, D., Furet, P.
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