CATH Domain 5np3D00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P42684

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P42684

ABL2_HUMAN

Homo sapiens

Tyrosine-protein kinase ABL2

PDB Structure

PDB	5NP3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. Mero, B., Radnai, L., Gogl, G., Toke, O., Leveles, I., Koprivanacz, K., Szeder, B., Dulk, M., Kudlik, G., Vas, V., Cserkaszky, A., Sipeki, S., Nyitray, L., Vertessy, B.G., Buday, L. J.Biol.Chem.