CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P42684
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P42684
ABL2_HUMAN
Homo sapiens
Tyrosine-protein kinase ABL2

PDB Structure

PDB 5NP3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
Mero, B., Radnai, L., Gogl, G., Toke, O., Leveles, I., Koprivanacz, K., Szeder, B., Dulk, M., Kudlik, G., Vas, V., Cserkaszky, A., Sipeki, S., Nyitray, L., Vertessy, B.G., Buday, L.
J.Biol.Chem.