CATH Classification

Domain Context

CATH Clusters

Superfamily Spasmolytic Protein, domain 1
Functional Family Lysosomal alpha-glucosidase

Enzyme Information

3.2.1.20
Alpha-glucosidase.
based on mapping to UniProt P10253
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
-!- Group of enzymes whose specificity is directed mainly toward the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyze oligosaccharides rapidly, relative to polysaccharides, which are hydrolyzed relatively slowly, or not at all. -!- The intestinal enzyme also hydrolyzes polysaccharides, catalyzing the reactions of EC 3.2.1.3, and, more slowly, hydrolyzes 1,6-alpha-D- glucose links.

UniProtKB Entries (1)

P10253
LYAG_HUMAN
Homo sapiens
Lysosomal alpha-glucosidase

PDB Structure

PDB 5NN8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease.
Roig-Zamboni, V., Cobucci-Ponzano, B., Iacono, R., Ferrara, M.C., Germany, S., Bourne, Y., Parenti, G., Moracci, M., Sulzenbacher, G.
Nat Commun