CATH Domain 5njjA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	protein numb isoform X1

Enzyme Information

UniProtKB Entries (1)

NUMB_HUMAN

Homo sapiens

Protein numb homolog

PDB Structure

PDB	5NJJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. Colaluca, I.N., Basile, A., Freiburger, L., D'Uva, V., Disalvatore, D., Vecchi, M., Confalonieri, S., Tosoni, D., Cecatiello, V., Malabarba, M.G., Yang, C.J., Kainosho, M., Sattler, M., Mapelli, M., Pece, S., Di Fiore, P.P. J. Cell Biol.