CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity protein kinase TTK

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P33981
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P33981
TTK_HUMAN
Homo sapiens
Dual specificity protein kinase TTK

PDB Structure

PDB 5MRB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
Hiruma, Y., Koch, A., Hazraty, N., Tsakou, F., Medema, R.H., Joosten, R.P., Perrakis, A.
J. Biol. Chem.