CATH Domain 5m2vA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Glutamate receptor ionotropic, kainate 1

Enzyme Information

UniProtKB Entries (1)

GRIK1_RAT

Rattus norvegicus

Glutamate receptor ionotropic, kainate 1

PDB Structure

PDB	5M2V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. Krogsgaard-Larsen, N., Delgar, C.G., Koch, K., Brown, P.M., Moller, C., Han, L., Huynh, T.H., Hansen, S.W., Nielsen, B., Bowie, D., Pickering, D.S., Kastrup, J.S., Frydenvang, K., Bunch, L. J. Med. Chem.