1 keywords

CATH Domain 5lz8A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1820 alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Platelet-activating factor acetylhydrolase

Enzyme Information

3.1.1.47
1-alkyl-2-acetylglycerophosphocholine esterase.
based on mapping to UniProt Q13093
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl- sn-glycero-3-phosphocholine + acetate.

UniProtKB Entries (1)

Q13093
PAFA_HUMAN
Homo sapiens
Platelet-activating factor acetylhydrolase

PDB Structure

PDB 5LZ8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
Woolford, A.J., Day, P.J., Beneton, V., Berdini, V., Coyle, J.E., Dudit, Y., Grondin, P., Huet, P., Lee, L.Y., Manas, E.S., McMenamin, R.L., Murray, C.W., Page, L.W., Patel, V.K., Potvain, F., Rich, S.J., Sang, Y., Somers, D.O., Trottet, L., Wan, Z., Zhang, X.
J. Med. Chem.