CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone acetyltransferase KAT2B

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.
2.3.1.57
Diamine N-acetyltransferase.
based on mapping to UniProt Q92831
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
-!- Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)- acetylspermidine and N(8)-acetylspermidine.

UniProtKB Entries (1)

Q92831
KAT2B_HUMAN
Homo sapiens
Histone acetyltransferase KAT2B

PDB Structure

PDB 5LVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
Navratilova, I., Aristotelous, T., Picaud, S., Chaikuad, A., Knapp, S., Filappakopoulos, P., Hopkins, A.L.
ACS Med Chem Lett
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