CATH Classification
Level | CATH Code | Description |
---|---|---|
![]() |
3 | Alpha Beta |
![]() |
3.40 | 3-Layer(aba) Sandwich |
![]() |
3.40.50 | Rossmann fold |
![]() |
3.40.50.10800 | NadA-like |
Domain Context
CATH Clusters
Superfamily | NadA-like |
Functional Family | Quinolinate synthase A |
Enzyme Information
2.5.1.72 |
Quinolinate synthase.
based on mapping to UniProt Q9X1X7
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
-!- Quinolinate synthase catalyzes the second step in the de novo biosynthesis of NAD(+) from aspartate in some bacteria, with EC 1.4.3.16 catalyzing the first step and EC 2.4.2.19 the third step. -!- In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme.
|
UniProtKB Entries (1)
Q9X1X7 |
NADA_THEMA
Thermotoga maritima MSB8
Quinolinate synthase A
|
PDB Structure
PDB | 5LQM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.
J.Am.Chem.Soc.
|