CATH Domain 5lqfA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Putative Cyclin-dependent kinase 1

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P06493

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

2.7.11.23

[RNA-polymerase]-subunit kinase.

based on mapping to UniProt P06493

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.

UniProtKB Entries (1)

P06493

CDK1_HUMAN

Homo sapiens

Cyclin-dependent kinase 1

PDB Structure

PDB	5LQF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. Coxon, C.R., Anscombe, E., Harnor, S.J., Martin, M.P., Carbain, B., Golding, B.T., Hardcastle, I.R., Harlow, L.K., Korolchuk, S., Matheson, C.J., Newell, D.R., Noble, M.E., Sivaprakasam, M., Tudhope, S.J., Turner, D.M., Wang, L.Z., Wedge, S.R., Wong, C., Griffin, R.J., Endicott, J.A., Cano, C. J. Med. Chem.